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Karaelmas Fen ve Mühendislik Dergisi / Karaelmas Science and Engineering Journal 2 (2), 1-12, 2012 Karaelmas Science and Engineering Journal Journal home page: http://fbd.karaelmas.edu.tr Artificial Rearing of Entomophagous Insects, with Emphasis on Nutrition and Parasitoids - General Outlines from Personal ExperienceSimon Grenier Former INRA Research Director - 6 Rue des Mésanges, 69680 CHASSIEU, France
Part 5: Adult Basic Life Support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Robert A. Berg, Robin Hemphill, Benjamin S. Abella, Tom P. Aufderheide, Diana M. Cave, Mary Fran Hazinski, E. Brooke Lerner, Thomas D. Rea, Michael R. Sayre and Circulation 2010;122;S685-S705
Brain Research 992 (2003) 69 – 75 Characterization of the GABAA receptor in the brain of the adult male bullfrog, Rana catesbeiana David M. Hollis*, Sunny K. Boyd Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA Accepted 21 August 2003 Little is known about the properties of GABA receptors in the amphibian brain. The GABAA receptor is widespread in the mammalian brain,
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Felix Malnig • Robyn O'Neil • Melissa Oresky • Claire Sherman Gahlberg GalleryCollege of DuPage425 Fawell Blvd.Glen Ellyn, IL 60137-6599www.cod.edu/gallery(630) 942-2321 Col ege of DuPage Letter from VermontBy Lori Waxman It's as beautiful and restful as ever in Vermont. We've been here nearly a week, and each morningwe run straight to the pond and plunge in, happy to wake up to cold, fresh water instead of theusual shower. Then coffee and breakfast on the cabin porch, which overlooks one of the mostmagnificent vistas of the Stowe Valley: Mount Mansfield soaring in the distance, its bare ski runssnaking down conifer slopes, to the north the dip of Smuggler's Notch winding its way to the nextvalley over. In between sits the Trapp Family Lodge, home of the famous singing Austrian family(really!). Behind us rises Pinnacle, with its dual peaks that we climb each year, winter and summeralike, and everywhere grow wild apples and raspberries almost ripe for the picking.
April 2014 FAIRY-RING CHAMPIGNON Marasmius oreades ContentsView from the Chair.2 The cultivation of edible fungi Stains and reagents.3 at Scutchers Acres.9 UK Fungus Day 2014.3 Lake District Foray, 2013.11 North West Fungus Group - April 2014 Page No. 1 PRESIDENT:Professor Bruce Ing, Clwyd Mycological Institute
Kentucky River Foothills Development Council, Inc. 1623 Foxhaven Drive/ P.O. Box 743 Richmond, KY 40476-0743 Nutrition for a Healthy Heart This handbook was produced by Kentucky River Foothills Development Council, Inc. Special thanks to Karen Bailey, April Stone, and Veronica Taylor who wrote the text and designed the layout. It is intended as a source for health and
Your Health Reimbursement Arrangement (HRA) dollars may be able to be used to pay for co-payments, co-insurance, and deductibles. But that's not all. You may also be able to use your HRA money to pay for many expenses in the following categories: Medical, Dental Care, Eye Care, and Over-the-Counter (OTC) medications. Eligible items can vary by employer, so check the specifics of your particular HRA plan.
JBA-06412; No of Pages 21 Contents lists available at Biotechnology Advances Research review paper Harnessing the power of enzymes for environmental stewardship Philippe Demarche, Charles Junghanns, Rakesh R. Nair, Spiros N. Agathos Earth & Life Institute, Laboratory of Bioengineering, Université Catholique de Louvain, Place Croix du Sud 2/19, 1348 Louvain-la-Neuve, Belgium
JOURNAL OF PETROLOGY Occurrence and Origin of Andalusite inPeraluminous Felsic Igneous Rocks D. BARRIE CLARKE1*, MICHAEL DORAIS2, BERNARD BARBARIN3,DAN BARKER4, BERNARDO CESARE5, GEOFFREY CLARKE6,MOHAMED EL BAGHDADI7, SASKIA ERDMANN1, HANS-JU ¨ RSTER8, MARIO GAETA9, BA¨RBEL GOTTESMANN8, REBECCA A. JAMIESON1, DANIEL J. KONTAK10, FRIEDRICHKOLLER11, CARLOS LEAL GOMES12, DAVID LONDON13,GEORGE B. MORGAN VI13, LUIS J. P. F. NEVES14, DAVID R. M.PATTISON15, ALCIDES J. S. C. PEREIRA14, MICHEL PICHAVANT16,CARLOS W. RAPELA17, AXEL D. RENNO18, SIMON RICHARDS19,MALCOLM ROBERTS20, ALESSANDRO ROTTURA21, JULIOSAAVEDRA22, ALCIDES NOBREGA SIAL23, ALEJANDRO J.TOSELLI24, JOSE M. UGIDOS25, PAVEL UHER26, CARLOSVILLASECA27, DARIO VISONA
USERS GUIDE ICPC-2 PLUS This guide consists of five Sections outlining the advantages of coding andclassifying your data, giving guidelines to the use of ICPC-2 PLUS and anumber of Appendices which are updated with each release.You may print parts of the guide, the whole document (≈ 54 pages) or use itas an "on line" version on your computer screen.To navigate through the guide click the to jump to thatSection or Appendix.
Centro Studi per la Pace www.studiperlapace.it UNIVERSITÀ DEGLI STUDI DI CATANIA FACOLTÀ DI SCIENZE POLITICHE DIRITTI UMANI UN APPROCCIO NORMATIVO PER UNA QUESTIONE DI GIUSTIZIA GLOBALE Candidato: Spoto Biagi Relatore: Prof. Fabrizio Sciacca Correlatore: Prof. Matteo Negro ANNO ACCADEMICO 2004-2005 Pubblicazioni Centro Studi per la Pace
IUFoST Scientific Information Bulletin (SIB) June 2011 SHIGA TOXIN PRODUCING Escherichia coli: GERMANY 2011 Escherichia coli O1O4:H4 OUTBREAK LINKED TO SPROUTED SEEDS Introduction The outbreak of Shiga Toxin producing Escherichia coli O104:H4 linked to bean sprouts led to over 3800 confirmed cases of illness that included more than 823 cases of Heamolytic Uremic Syndrome (HUS) and 44 deaths (Frank et al., 2011). Although it appeared that the O104:H4 serotype came from nowhere the pathogen had actually been isolated in Germany 10 years ago. The outbreak in Germany was more a consequence of two vulnerabilities (highly virulent pathogen and a high risk food) within the food chain coming together with disastrous consequences. The purpose of this Scientific Information Bulletin (SIB) is to provide background into Shiga Toxin Escherichia coli and how the O104:H4 serotype has changed our understanding of pathogenicity of E. coli. The future challenges in controlling STEC and research needs will also be discussed. Escherichia coli E. coli is encountered in the gastrointestinal tract of all warm blooded animals including humans. The bacterium has a close relationship with mammals that was established some 140 million years ago when the first rodents appeared on the Earth. The vast majority of E. coli are non-pathogenic and actually are essential for health. For example, E. coli produces Vitamin K that we use as part of cell repair (blood clotting) and are far more effective probiotics than lactic acid bacteria in out-competing would be pathogens such as Salmonella and Clostridium difficile. E. coli has also found utility as an indicator for fecal contamination in foods and water. Its presence indicates the potential presence of virulent pathogens such as Salmonella, E. coli O157 and Shigella, amongst others. Finally, E. coli has been the workhorse of molecular biology and provided a wealth of information on the function of genes and how these can be manipulated to produce valuable products such as insulin used to treat diabetes. One of the main features that makes E. coli easy to manipulate in genetic engineering is the ease with which genetic material can be introduced and alter the physiological traits of the bacterium. Indeed, it is the acquisition of genes that gave rise to a sub-set of E. coli termed pathogenic E. coli. The pathogenic E. coli can be sub-grouped on the mode by which they cause illness and are classified as Enteropathogenic E. coli (EPEC), Entero-toxigenic E. coli (ETEC), Entero-Diffuse E. coli (EDEC) and Entero Invasive E. coli (EIEC). The additional two groups of relevance here are Entero Aggregative E. coli (EAggEC) and Shiga Toxin Producing E. coli. Shiga Toxin Producing Escherichia coli Escherichia coli harboring shiga toxin(s) genes collectively fall with the STEC group and encompasses over 200 different serotypes (Couturier et al.. 2011; Lindqvist et al., 2011; Mathusa et al., 2010). The different serotypes making up the STEC group were known since the 1980ʼs but apart from O157 were
European Scientific Journal September 2013 edition vol.9, No.27 ISSN: 1857 – 7881 (Print) e - ISSN 1857- 7431 DISCRIMINANT ANALYSIS AND MAHALANOBIS DISTANCE (NIR DIFFUSE REFLECTANCE SPECTRA) IN THE ASSESSMENT OF DRUG'S BATCH-TO-BATCH DISPERSION AND QUALITY THRESHOLD Maria Morozova, PhD
Pasado Abierto. Revista del CEHis. (247-250) Reseña de Cepeda, Agustina y Rustoyburu, Cecilia (Comps.) (2014), De las hormonas sexuadas al Viagra. Ciencia, Medicina y Sexualidad en Argentina y Brasil. Mar del Plata: EUDEM. 301 páginas. ISBN: 978-987-1921-27-0. Natacha Mateo Universidad Nacional de Mar del Plata
Peace Corps May 1, 1964 TABLE OF CONTENTS B. THE VOLUNTEER ROLE IN THAILAND C. PEACE CORPS STAFF . F. LANGUAGE STUDY G. TECHNICAL AIDS H. REIMBURSEMENT I. MAIL AND CUSTOMS J. HEALTH AND MEDICAL SUPPORT K. ANNUAL LEAVE AND TRAVEL L. VOLUNTEER READING AND RELATED SERVICES " 21 M. VEHICLES AND LICENSES N. MARRIAGE POLICY O. TERMINATION OF SERVICE, EXTENSION OF SERVICE AND RE-ENROLLMENT
consists of an advanced technology, based on the combination of an algi- Local treatment of burns: nate gel with a patented antibacterial enzyme system: when bacteria come a modern approach. into contact with Flaminal® Forte, a se-ries of enzyme reactions are triggered that ultimately result in the production In recent years, much research has been conducted with an aim to
Autobiografía de San Ignacio de Loyola – P.Luis Goncalves AUTOBIOGRAFIA DE SAN IGNACIO DE LOYOLA (Texto recogido por el P. Luis Goncalves da Camara entre 1553 y 1555 Capítulo I 1. Hasta los 26 años de edad fue hombre dado a vantado, que era cosa fea; lo cual él no pudiendo las vanidades del mundo y principalmente se sufrir, porque determinaba seguir el mundo, y
THE FAULT IN OUR STARS Scott Neustadter & Michael H. Weber Based on the novel by John Green FOX 2000 PICTURES FINAL SHOOTING SCRIPT 10201 W. Pico Blvd. Los Angeles, CA 90035 Revisions Green – August 27, 2013 Yellow – August 30, 2013 Goldenrod – September 13, 2013 Salmon – September 18, 2013 2nd Blue – September 23, 2013
XIV Conferencia de Tribunales Constitucionales Europeos Vilna, - de mayo de 2008 Los problemas de la omisión legislativa en la jurisprudencia constitucional Ponencia del Tribunal Constitucional de España Ponente: Letrado: Juan Luis Requejo Pagés 1. LA PROBLEMÁTICA DE LOS VACÍOS NORMATIVOS EN LA DOCTRINA CIENTÍFICA. 1.1. El concepto de "vacío normativo". 1.2. El concepto de "omisión legislativa". 1.3. La concepción del Tribunal Constitucional como legislador "positivo" o "negativo". 2. ESTABLECIMIENTO DEL CONTROL DE CONSTITUCIONALIDAD DE LAS OMISIONES LEGISLATIVAS EN LA CONSTITUCIÓN, EN OTRAS DISPOSICIONES O EN LA JURISPRUDENCIA CONSTITUCIONAL. 2.1. La Constitución en el sistema jurídico nacional. 2.2. Previsiones constitucionales expresas respecto de la jurisdicción del Tribunal Constitucional para examinar y determinar la constitucionalidad de los vacíos normativos. 2.3. Interpretación por la jurisprudencia constitucional de la jurisdicción del Tribunal Constitucional para examinar y determinar la constitucionalidad de vacíos normativos. 2.4. Establecimiento, bien en la ley reguladora de la actividad del Tribunal Constitucional, bien en otro texto legal, de la jurisdicción del Tribunal Constitucional para examinar y determinar la constitucionalidad de vacíos normativos. 3. LA OMISIÓN LEGISLATIVA COMO OBJETO DE CONOCIMIENTO POR EL TRIBUNAL CONSTITUCIONAL. 3.1. Legitimación para acceder al Tribunal Constitucional. 3.2. La omisión legislativa en las demandas de los recurrentes. 3.3. Examen de omisiones legislativas a iniciativa del Tribunal Constitucional. 3.4. Omisiones legislativas en leyes y otras normas jurídicas. 3.5. Negativa del Tribunal Constitucional a examinar vacíos normativos. 3.6. Iniciativa de examen de la "naturaleza conexa" ("related nature"). 4. EXAMEN Y DETERMINACIÓN DE LA CONSTITUCIONALIDAD DE LAS OMISIONES LEGISLATIVAS. 4.1. Peculiaridades del examen de las omisiones legislativas. 4.2. Constatación de la existencia de omisiones legislativas. 4.3. Metodología para el descubrimiento de omisiones legislativas. 4.4. Medidas adicionales. 4.5. Supuestos en que el Tribunal Constitucional examina las omisiones legislativas como parte del examen de los casos de justicia constitucional, pero sin resolver sobre su constitucionalidad. 4.6. Resolución sobre la omisión legislativa en el fallo de la decisión del Tribunal Constitucional. 4.7. El examen y las decisiones relativas a la "naturaleza conexa" ("related nature"). 4.8. Técnicas jurídicas empleadas por el Tribunal Constitucional para evitar la aparición de vacíos normativos como consecuencia de decisiones que declaran contraria a la Constitución una ley u otra norma jurídica. 5. CONSECUENCIAS DE LA CONSTATACIÓN POR EL TRIBUNAL CONSTITUCIONAL DE LA EXISTENCIA DE OMISIONES LEGISLATIVAS. 5.1. Deberes para el legislador. 5.2. Deberes de otro poderes normadores. 6. CONCLUSIONES
Apple - 1 mediumBeetroot - 1 mediumCarrots - 8 mediumCelery - 2 stalk, largeSpinach - 3 cup Process all ingredients in your Optimum 400 Juicer, shake or stir and serve. Apples - 2 mediumCelery - 2 stalk, largePears - 2 mediumSweet Potato - 1, 5 inches long Process all ingredients in your Optimum 400 Juicer, shake or stir and serve. 03. FRESH BEET CARROT APPLE & GINGER JUICE
Consejo Regional Santiago Colegio Médico de Chile A.G. Dr. Pablo Araya Baltra Elaboración de contenidos Dr. Rafael Ferrer B. Dr. Jorge Cuevas M. Dr. Claudio Caro T. Diseño y Diagramación Marcos Pizarro C. Impresión Alerce Talleres Gráfi cos Sitios Web www.regionalsantiago.cl - www.naf2010.cl
Something to do with a girl named Marla Singer Journal Title: Free Associations: Psychoanalysis and Culture, Media, Groups, Politics Number 62, September 2011 ISSN: 2047-0622 URL: www.freeassociations.org.uk SOMETHING TO DO WITH A GIRL NAMED MARLA SINGER: CAPITALISM, NARCISSISM, AND THERAPEUTIC DISCOURSE IN DAVID
Improving journal club presentations, or, I canpresent that paper in under 10 minutes Mark D Schwartz, Deborah Dowell, Jaclyn Aperi and Adina L Kalet Evid. Based Med. 2007;12;66-68 doi:10.1136/ebm.12.3.66-a Updated information and services can be found at: These include: This article cites 5 articles, 3 of which can be accessed free at:
LA ECONOMÍA Y LA FILOSOFÍA DE LA LIBERTAD Alejandro Chafuén* En este ensayo se señala la importancia que la filosofía de la libertad tie-ne para la ciencia económica. Luego de un análisis comparativo de las de-finiciones de ciencia económica y de la filosofía de la libertad, el autorllega a la conclusión de que esta última provee el punto de partida de laeconomía. Esta, a su vez, al estar compuesta por deducciones del princi-pio de la acción humana (que es voluntaria y libre), aumenta nuestrosconocimientos de las implicancias de la libertad mejorando por tantonuestra filosofía libertaria. Como conclusión, se describen algunos argu-mentos de economistas liberales demostrando que la intervención econó-mica es en la vida contemporánea el arma más eficaz y sutil que tienenlos gobernantes para coartar la libertad de los individuos.
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What Drives the 10-year Cycle of Snowshoe Hares? CHARLES J. KREBS, RUDY BOONSTRA, STAN BOUTIN AND A.R.E. SINCLAIR In 1831 the manager of a Hudson's Bay Company post in northern Ontario wrote to the head office in London. THE TEN-YEAR CYCLE OF SNOWSHOE The local Ojibway Indians were starving, he reported, becauseof a scarcity of "rabbits," and they were unable to trap for furs
Contents lists available at Journal of Chromatography A Recent developments in liquid chromatography–mass spectrometry and related Michal Holˇcapek , Robert Jirásko, Miroslav Lísa Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 53210 Pardubice, Czech Republic This review summarizes the state-of-art in liquid chromatography–mass spectrometry (LC–MS) and
Donahay e, E.J., Nav arro, S. and Leesch J.G. [Eds.] (2001) Proc. Int. Conf. Controlled Atmosphereand Fumigation in Stored Products, Fresno, CA. 29 Oct. - 3 Nov . 2000, Executive PrintingServices, Clovis, CA, U.S.A. pp. 79-89 METABOLISM OF CARBONYL SULFIDE TO HYDROGEN SULFIDE IN INSECTS IS CATALYSED BY CARBONIC ANHYDRASE Stored Grain Research Laboratory, CSIRO Entomology, Canberra, ACT 2601, Australia
Difficultés du suivi du dément Prendre en charge à domicile un patient souffrant de démence, et vivant parfois seul, est un défi permanent pour le médecin généraliste. S'appuyant sur une vignette clinique décrivant l'histoire d'une patiente âgée démente, la prise en charge et le traitement sont abordés dans cet article, notamment l'annonce du diagnostic, les éléments majeurs à aborder avec le patient et sa famille, l'état confusionnel, la révision médicamenteuse, les troubles du comportement, l'alimentation, le traitement des
MENGENAL TENTANG MIASTENIA GRAVIS DAN Fahrun Nur Rosyid Bagian Keperawatan Medikal Bedah Fakultas Ilmu Kesehatan Universitas Muhammadiyah Surabaya Email: [email protected] Abstract Myastenia gravis may cause paralysis due to the mobility of neuromuscular connections to deliver signals from nerve fibers to muscle fiber. This disease occurs due to disruption of synaptic transmission at neuromuscular junction. Prior understanding of myastenia gravis, knowledge of anatomy and normal function of the neuromuscular junction is very important. Presinaptic membrane (membrane of nerve), post synaptic membrane (muscle membrane), and the synapse is a gap forming parts of the neuromuscular junction. Immunoigenic mechanism plays a very important in the pathophysiology myastenia gravis where antibodies are the product ofB cells in fact against the acethylcholine receptor. Management myasatenia gravis can be done with drugs thymomectomy or with immunomodulating and immunosuppressive therapy that can provide a good prognosis in mystenia gravis healing. Key word: Mystenia gravis, and management. PENDAHULUAN
Contents lists available at Cannabinoid CB1 receptor in the modulation of stress coping behavior in mice:The role of serotonin and different forebrain neuronal subpopulations M. Häring , M. Grieb , K. Monory , B. Lutz F.A. Moreira a Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germanyb Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil
Published May 3, 1999 Inhibition of T Cell Proliferation by MacrophageTryptophan Catabolism By David H. Munn,*‡ Ebrahim Shafizadeh,* John T. Attwood,*Igor Bondarev,* Achal Pashine,* and Andrew L. Mellor* From the *Institute of Molecular Medicine and Genetics and the ‡Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912
OF ECONOMICS AND GOVERNMENT Richard MulganSatish ChandPeter Larmour ANU COLLEGE OF ASIA & THE PACIFIC Corruption and Anti-Corruption Richard Mulgan, Satish Chand & Peter Larmour Crawford School of Economics and Government ContentsDemocracy and political corruption:idealism versus realismRichard Mulgan Are free trips and payments topoliticians bribes?Satish Chand Diagnosing the disease of corruption:what different disciplines suggestabout curing corruptionPeter Larmour
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Alternative Dispute Resolution in India A study on concepts, techniques, provisions, problems in implementation and solutions Submitted to: Lok Satta Student, Ist year, IInd semester NALSAR University of Law Table of Contents Study of ADR institutions across the world Reasons behind introduction of ADR in India The Arbitration and Conciliation Act, 1996 Lok Adalats as a unique ADR measure in India
Global Listed Infrastructure Monthly Review and Outlook As at June 2014 Welcome to the latest monthly update on the First State Global Infrastructure, providing a review of the Fund and latest outlook Key highlights: Global listed infrastructure capped the 2013/2014 financial year with a further increase in June. The Fund climbed by 0.9%; its seventh consecutive month of positive returns. The regulated utility and energy pipeline sectors hummed with M&A activity and corporate re-structurings. Fund positioning remains tilted towards "growth" oriented sectors such as toll roads, ports and railways. Underweight exposure has been maintained towards "income" sectors such as regulated utilities and energy pipelines that
Als Hauptsponsor des Bundessängerfest 2008 in Balzers, dem wichtigsten Anlass der Sängerinnen und Sänger in Liechtenstein, freuen wir uns ganz besonders auf ein interessantes Wertungssingen und viele singende und klingende Melodien. Wir wünschen den Sängerinnen und Sängern viel Erfolg und Freude. Kaiser treuhand, Balzers, ist besonders stolz als Hauptsponsor des Bundessängerfest 2008 in Bal-zers dabei zu sein und zum grössten landesweiten Sängerfest durch unsere unterstützung zum guten gelingen beitragen zu dürfen.
Numéro 1 - Juillet 2013 AU SOMMAIRE Le recours à des méthodes alternatives en expérimentation FRANCOPA en bref animale est aujourd'hui une nécessité, eu égard notamment Infocentre aux exigences du règlement REACh qui requiert des résultats Point sur les méthodes alternatives rapides et fiables sur les propriétés toxiques et écotoxiques Quelques partenaires de FRANCOPA
Multiple Sclerosis DIAGNOSED IN 2000 Multiple SclerosisBY DEBR A FR ANKEL, MS, OTR WITH HETTIE JAMES Debra Frankel, MS, OTR is Vice President of Healthcare Access Initiatives for the Advocacy, Services and Research Department at the National MS Society. Hettie Jones is a professional writer. Reviewed by: Pat Bednarik, MS, CCC-SLP, MSCS; Adrienne Boissy, MD; James Bowen, MD; Sharon Dodge, MS activist; George Garmany, MD; Barbara Giesser, MD; and Pat Kennedy, RN, CNP, MSCN
Available online at www.sciencedirect.com Schizophrenia Research 105 (2008) 49 – 60 Static posed and evoked facial expressions of emotions Christian G. Kohler ⁎, Elizabeth A. Martin, Neal Stolar, Fred S. Barrett, Ragini Verma, Colleen Brensinger, Warren Bilker, Raquel E. Gur, Ruben C. Gur Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States
lega italiana per la lot a contro la malatia di parkinson le sindromiextrapiramidali e le demenze Linee Guida per il Trattamento della Malattia di Parkinson 2002 Guest Editor: Prof. B. Bergamasco (Torino) Prof. Giovanni Abbruzzese (Genova) Prof. Alberto Albanese (Milano) Dr. Angelo Antonini (Milano) Dr. Paolo Barone (Napoli) Dr. Vincenzo Bonifati (Roma)
JOURNAL OF BONE AND MINERAL RESEARCHVolume 12, Number 10, 1997Blackwell Science, Inc.© 1997 American Society for Bone and Mineral Research Long-Term Effects of Intravenous Pamidronate in Fibrous Dysplasia of Bone ROLAND D. CHAPURLAT,1 PIERRE D. DELMAS,1,2 DANIEL LIENS,1 and PIERRE J. MEUNIER1 Fibrous dysplasia of bone (FD) is a rare disorder characterized by proliferation of fibrous tissue in bone marrowleading to osteolytic lesions. It causes bone pain and fractures. To date the only treatment is orthopedic.Histological and biochemical similarities between FD and Paget's bone disease related to increased osteoclasticresorption led us to propose treatment with the bisphosphonate pamidronate. The aim of the study was to assessthe long-term effects of intravenous pamidronate in FD. In this open label phase III study, 20 patients with FD (11males and 9 females; mean age 31 years) received courses of 180 mg of intravenous pamidronate every 6 months(60 mg/day during 3 days by infusion). The mean duration of follow-up was 39 months (range 18 – 64). Severity ofbone pain, number of painful skeletal sites per patient, X-rays of all involved areas, serum alkaline phosphatase,fasting urinary hydroxyproline, and urinary type I collagen C-telopeptide were assessed every 6 months. Theseverity of bone pain and the number of painful sites appeared to be significantly reduced. All biochemical markersof bone remodeling were substantially lowered. We observed a radiographic response in nine patients with refillingof osteolytic lesions. A mineralization defect proven by bone biopsy was observed in one case. Four patientssustained bone stress lines, but no fracture occurred. We suggest that intravenous pamidronate alleviates bonepain, reduces the rate of bone turnover assessed by biochemical markers, and improves radiological lesions of FD.Few side effects were observed. (J Bone Miner Res 1997;12:1746–1752)
Prepared by DeHavilland Information Services plc on behalf of the FDIN News stories January 1st-31st 2005 Vitamin C 'may protect against allergies' Date: Tue, 04 Jan 05 Type: DirectNews Item Analysis Women who eat a lot of foods rich in vitamin C while breastfeeding may be protecting their children from developing allergies, according to a new study. Scientists writing in the latest edition of the European Journal of Clinical Nutrition claim
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Mandala et al. BMC Pharmacology and Toxicology 2014, 15:77http://www.biomedcentral.com/2050-6511/15/77 Liver and renal safety of tenofovir disoproxilfumarate in combination with emtricitabineamong African women in a pre-exposureprophylaxis trial Justin Mandala1*, Kavita Nanda2, Meng Wang2, Irith De Baetselier3, Jennifer Deese2, Johan Lombaard4,Fredrick Owino5, Mookho Malahleha6, Rachel Manongi7, Douglas Taylor2 and Lut Van Damme1,8