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Brain Research 992 (2003) 69 – 75 Characterization of the GABAA receptor in the brain of the adult male bullfrog, Rana catesbeiana David M. Hollis*, Sunny K. Boyd Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA Accepted 21 August 2003 Little is known about the properties of GABA receptors in the amphibian brain. The GABAA receptor is widespread in the mammalian brain,

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IUFoST Scientific Information Bulletin (SIB) June 2011 SHIGA TOXIN PRODUCING Escherichia coli: GERMANY 2011 Escherichia coli O1O4:H4 OUTBREAK LINKED TO SPROUTED SEEDS Introduction The outbreak of Shiga Toxin producing Escherichia coli O104:H4 linked to bean sprouts led to over 3800 confirmed cases of illness that included more than 823 cases of Heamolytic Uremic Syndrome (HUS) and 44 deaths (Frank et al., 2011). Although it appeared that the O104:H4 serotype came from nowhere the pathogen had actually been isolated in Germany 10 years ago. The outbreak in Germany was more a consequence of two vulnerabilities (highly virulent pathogen and a high risk food) within the food chain coming together with disastrous consequences. The purpose of this Scientific Information Bulletin (SIB) is to provide background into Shiga Toxin Escherichia coli and how the O104:H4 serotype has changed our understanding of pathogenicity of E. coli. The future challenges in controlling STEC and research needs will also be discussed. Escherichia coli E. coli is encountered in the gastrointestinal tract of all warm blooded animals including humans. The bacterium has a close relationship with mammals that was established some 140 million years ago when the first rodents appeared on the Earth. The vast majority of E. coli are non-pathogenic and actually are essential for health. For example, E. coli produces Vitamin K that we use as part of cell repair (blood clotting) and are far more effective probiotics than lactic acid bacteria in out-competing would be pathogens such as Salmonella and Clostridium difficile. E. coli has also found utility as an indicator for fecal contamination in foods and water. Its presence indicates the potential presence of virulent pathogens such as Salmonella, E. coli O157 and Shigella, amongst others. Finally, E. coli has been the workhorse of molecular biology and provided a wealth of information on the function of genes and how these can be manipulated to produce valuable products such as insulin used to treat diabetes. One of the main features that makes E. coli easy to manipulate in genetic engineering is the ease with which genetic material can be introduced and alter the physiological traits of the bacterium. Indeed, it is the acquisition of genes that gave rise to a sub-set of E. coli termed pathogenic E. coli. The pathogenic E. coli can be sub-grouped on the mode by which they cause illness and are classified as Enteropathogenic E. coli (EPEC), Entero-toxigenic E. coli (ETEC), Entero-Diffuse E. coli (EDEC) and Entero Invasive E. coli (EIEC). The additional two groups of relevance here are Entero Aggregative E. coli (EAggEC) and Shiga Toxin Producing E. coli. Shiga Toxin Producing Escherichia coli Escherichia coli harboring shiga toxin(s) genes collectively fall with the STEC group and encompasses over 200 different serotypes (Couturier et al.. 2011; Lindqvist et al., 2011; Mathusa et al., 2010). The different serotypes making up the STEC group were known since the 1980ʼs but apart from O157 were

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European Scientific Journal September 2013 edition vol.9, No.27 ISSN: 1857 – 7881 (Print) e - ISSN 1857- 7431 DISCRIMINANT ANALYSIS AND MAHALANOBIS DISTANCE (NIR DIFFUSE REFLECTANCE SPECTRA) IN THE ASSESSMENT OF DRUG'S BATCH-TO-BATCH DISPERSION AND QUALITY THRESHOLD Maria Morozova, PhD

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XIV Conferencia de Tribunales Constitucionales Europeos Vilna, - de mayo de 2008 Los problemas de la omisión legislativa en la jurisprudencia constitucional Ponencia del Tribunal Constitucional de España Ponente: Letrado: Juan Luis Requejo Pagés 1. LA PROBLEMÁTICA DE LOS VACÍOS NORMATIVOS EN LA DOCTRINA CIENTÍFICA. 1.1. El concepto de "vacío normativo". 1.2. El concepto de "omisión legislativa". 1.3. La concepción del Tribunal Constitucional como legislador "positivo" o "negativo". 2. ESTABLECIMIENTO DEL CONTROL DE CONSTITUCIONALIDAD DE LAS OMISIONES LEGISLATIVAS EN LA CONSTITUCIÓN, EN OTRAS DISPOSICIONES O EN LA JURISPRUDENCIA CONSTITUCIONAL. 2.1. La Constitución en el sistema jurídico nacional. 2.2. Previsiones constitucionales expresas respecto de la jurisdicción del Tribunal Constitucional para examinar y determinar la constitucionalidad de los vacíos normativos. 2.3. Interpretación por la jurisprudencia constitucional de la jurisdicción del Tribunal Constitucional para examinar y determinar la constitucionalidad de vacíos normativos. 2.4. Establecimiento, bien en la ley reguladora de la actividad del Tribunal Constitucional, bien en otro texto legal, de la jurisdicción del Tribunal Constitucional para examinar y determinar la constitucionalidad de vacíos normativos. 3. LA OMISIÓN LEGISLATIVA COMO OBJETO DE CONOCIMIENTO POR EL TRIBUNAL CONSTITUCIONAL. 3.1. Legitimación para acceder al Tribunal Constitucional. 3.2. La omisión legislativa en las demandas de los recurrentes. 3.3. Examen de omisiones legislativas a iniciativa del Tribunal Constitucional. 3.4. Omisiones legislativas en leyes y otras normas jurídicas. 3.5. Negativa del Tribunal Constitucional a examinar vacíos normativos. 3.6. Iniciativa de examen de la "naturaleza conexa" ("related nature"). 4. EXAMEN Y DETERMINACIÓN DE LA CONSTITUCIONALIDAD DE LAS OMISIONES LEGISLATIVAS. 4.1. Peculiaridades del examen de las omisiones legislativas. 4.2. Constatación de la existencia de omisiones legislativas. 4.3. Metodología para el descubrimiento de omisiones legislativas. 4.4. Medidas adicionales. 4.5. Supuestos en que el Tribunal Constitucional examina las omisiones legislativas como parte del examen de los casos de justicia constitucional, pero sin resolver sobre su constitucionalidad. 4.6. Resolución sobre la omisión legislativa en el fallo de la decisión del Tribunal Constitucional. 4.7. El examen y las decisiones relativas a la "naturaleza conexa" ("related nature"). 4.8. Técnicas jurídicas empleadas por el Tribunal Constitucional para evitar la aparición de vacíos normativos como consecuencia de decisiones que declaran contraria a la Constitución una ley u otra norma jurídica. 5. CONSECUENCIAS DE LA CONSTATACIÓN POR EL TRIBUNAL CONSTITUCIONAL DE LA EXISTENCIA DE OMISIONES LEGISLATIVAS. 5.1. Deberes para el legislador. 5.2. Deberes de otro poderes normadores. 6. CONCLUSIONES

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LA ECONOMÍA Y LA FILOSOFÍA DE LA LIBERTAD Alejandro Chafuén* En este ensayo se señala la importancia que la filosofía de la libertad tie-ne para la ciencia económica. Luego de un análisis comparativo de las de-finiciones de ciencia económica y de la filosofía de la libertad, el autorllega a la conclusión de que esta última provee el punto de partida de laeconomía. Esta, a su vez, al estar compuesta por deducciones del princi-pio de la acción humana (que es voluntaria y libre), aumenta nuestrosconocimientos de las implicancias de la libertad mejorando por tantonuestra filosofía libertaria. Como conclusión, se describen algunos argu-mentos de economistas liberales demostrando que la intervención econó-mica es en la vida contemporánea el arma más eficaz y sutil que tienenlos gobernantes para coartar la libertad de los individuos.

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What Drives the 10-year Cycle of Snowshoe Hares? CHARLES J. KREBS, RUDY BOONSTRA, STAN BOUTIN AND A.R.E. SINCLAIR In 1831 the manager of a Hudson's Bay Company post in northern Ontario wrote to the head office in London. THE TEN-YEAR CYCLE OF SNOWSHOE The local Ojibway Indians were starving, he reported, becauseof a scarcity of "rabbits," and they were unable to trap for furs

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MENGENAL TENTANG MIASTENIA GRAVIS DAN Fahrun Nur Rosyid Bagian Keperawatan Medikal Bedah Fakultas Ilmu Kesehatan Universitas Muhammadiyah Surabaya Email: fahrunrosyid@yahoo.co.id Abstract Myastenia gravis may cause paralysis due to the mobility of neuromuscular connections to deliver signals from nerve fibers to muscle fiber. This disease occurs due to disruption of synaptic transmission at neuromuscular junction. Prior understanding of myastenia gravis, knowledge of anatomy and normal function of the neuromuscular junction is very important. Presinaptic membrane (membrane of nerve), post synaptic membrane (muscle membrane), and the synapse is a gap forming parts of the neuromuscular junction. Immunoigenic mechanism plays a very important in the pathophysiology myastenia gravis where antibodies are the product ofB cells in fact against the acethylcholine receptor. Management myasatenia gravis can be done with drugs thymomectomy or with immunomodulating and immunosuppressive therapy that can provide a good prognosis in mystenia gravis healing. Key word: Mystenia gravis, and management. PENDAHULUAN

Cannabinoid cb1 receptor in the modulation of stress coping behavior in mice: the role of serotonin and different forebrain neuronal subpopulations

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Published May 3, 1999 Inhibition of T Cell Proliferation by MacrophageTryptophan Catabolism By David H. Munn,*‡ Ebrahim Shafizadeh,* John T. Attwood,*Igor Bondarev,* Achal Pashine,* and Andrew L. Mellor* From the *Institute of Molecular Medicine and Genetics and the ‡Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912

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OF ECONOMICS AND GOVERNMENT Richard MulganSatish ChandPeter Larmour ANU COLLEGE OF ASIA & THE PACIFIC Corruption and Anti-Corruption Richard Mulgan, Satish Chand & Peter Larmour Crawford School of Economics and Government ContentsDemocracy and political corruption:idealism versus realismRichard Mulgan Are free trips and payments topoliticians bribes?Satish Chand Diagnosing the disease of corruption:what different disciplines suggestabout curing corruptionPeter Larmour

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Alternative Dispute Resolution in India A study on concepts, techniques, provisions, problems in implementation and solutions Submitted to: Lok Satta Student, Ist year, IInd semester NALSAR University of Law Table of Contents Study of ADR institutions across the world Reasons behind introduction of ADR in India The Arbitration and Conciliation Act, 1996 Lok Adalats as a unique ADR measure in India

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Numéro 1 - Juillet 2013 AU SOMMAIRE Le recours à des méthodes alternatives en expérimentation FRANCOPA en bref animale est aujourd'hui une nécessité, eu égard notamment Infocentre aux exigences du règlement REACh qui requiert des résultats Point sur les méthodes alternatives rapides et fiables sur les propriétés toxiques et écotoxiques Quelques partenaires de FRANCOPA

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Doi:10.1016/j.schres.2008.05.010

Available online at www.sciencedirect.com Schizophrenia Research 105 (2008) 49 – 60 Static posed and evoked facial expressions of emotions Christian G. Kohler ⁎, Elizabeth A. Martin, Neal Stolar, Fred S. Barrett, Ragini Verma, Colleen Brensinger, Warren Bilker, Raquel E. Gur, Ruben C. Gur Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

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JOURNAL OF BONE AND MINERAL RESEARCHVolume 12, Number 10, 1997Blackwell Science, Inc.© 1997 American Society for Bone and Mineral Research Long-Term Effects of Intravenous Pamidronate in Fibrous Dysplasia of Bone ROLAND D. CHAPURLAT,1 PIERRE D. DELMAS,1,2 DANIEL LIENS,1 and PIERRE J. MEUNIER1 Fibrous dysplasia of bone (FD) is a rare disorder characterized by proliferation of fibrous tissue in bone marrowleading to osteolytic lesions. It causes bone pain and fractures. To date the only treatment is orthopedic.Histological and biochemical similarities between FD and Paget's bone disease related to increased osteoclasticresorption led us to propose treatment with the bisphosphonate pamidronate. The aim of the study was to assessthe long-term effects of intravenous pamidronate in FD. In this open label phase III study, 20 patients with FD (11males and 9 females; mean age 31 years) received courses of 180 mg of intravenous pamidronate every 6 months(60 mg/day during 3 days by infusion). The mean duration of follow-up was 39 months (range 18 – 64). Severity ofbone pain, number of painful skeletal sites per patient, X-rays of all involved areas, serum alkaline phosphatase,fasting urinary hydroxyproline, and urinary type I collagen C-telopeptide were assessed every 6 months. Theseverity of bone pain and the number of painful sites appeared to be significantly reduced. All biochemical markersof bone remodeling were substantially lowered. We observed a radiographic response in nine patients with refillingof osteolytic lesions. A mineralization defect proven by bone biopsy was observed in one case. Four patientssustained bone stress lines, but no fracture occurred. We suggest that intravenous pamidronate alleviates bonepain, reduces the rate of bone turnover assessed by biochemical markers, and improves radiological lesions of FD.Few side effects were observed. (J Bone Miner Res 1997;12:1746–1752)

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Prepared by DeHavilland Information Services plc on behalf of the FDIN News stories January 1st-31st 2005 Vitamin C 'may protect against allergies' Date: Tue, 04 Jan 05 Type: DirectNews Item Analysis Women who eat a lot of foods rich in vitamin C while breastfeeding may be protecting their children from developing allergies, according to a new study. Scientists writing in the latest edition of the European Journal of Clinical Nutrition claim

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Liver and renal safety of tenofovir disoproxil fumarate in combination with emtricitabine among african women in a pre-exposure prophylaxis trial

Mandala et al. BMC Pharmacology and Toxicology 2014, 15:77http://www.biomedcentral.com/2050-6511/15/77 Liver and renal safety of tenofovir disoproxilfumarate in combination with emtricitabineamong African women in a pre-exposureprophylaxis trial Justin Mandala1*, Kavita Nanda2, Meng Wang2, Irith De Baetselier3, Jennifer Deese2, Johan Lombaard4,Fredrick Owino5, Mookho Malahleha6, Rachel Manongi7, Douglas Taylor2 and Lut Van Damme1,8